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Those on insulin or insulin secretagogues were more likely to develop solid cancers than those on metformin, and combination with metformin abolished most of this excess risk.
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In an attempt to characterize the mechanism by which metformin affects the biology of b-cell lymphoma, we studied its effect on rituximab activity.
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As reported previously 32 , metformin could promote reductive glutamine metabolism in 143b wt cells generation of m 5 citrate from u- 13 c -glutamine , while 143b cytb cells displayed reductive carboxylation even in the absence of metformin fig 5c .